Taxane-Induced Peripheral Neurotoxicity

Taxane-Induced Peripheral Neurotoxicity

Taxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel are most commonly administered, but newer formulations are being investigated. Taxane antineoplastic activity is mainly based on the ability of the drugs to promote microtubule assembly, leading to mitotic arrest and apoptosis in cancer cells. Peripheral neurotoxicity is the ma...

Cumulative genetic risk predicts platinum/taxane-induced neurotoxicity.

PURPOSE The combination of a platinum and taxane are standard of care for many cancers, but the utility is often limited due to debilitating neurotoxicity. We examined whether single-nucleotide polymorphisms (SNP) from annotated candidate genes will identify genetic risk for chemotherapy-induced neurotoxicity. PATIENTS AND METHODS A candidate-gene association study was conducted to validate t...

Updates on Oxaliplatin-Induced Peripheral Neurotoxicity (OXAIPN)

Oxaliplatin-induced peripheral neuropathy (OXAIPN) is of great clinical interest as it ranks among the most common dose limiting toxicities of oxaliplatin (OXA) administration with an obvious impact on the outcome of cancer patients. In addition, OXAIPN has a detrimental effect on the quality of life of cancer patients because it can be long lasting or even permanent. It has a unique spectrum o...

Predictive Biomarkers and Personalized Medicine Cumulative Genetic Risk Predicts Platinum/Taxane-Induced Neurotoxicity

Purpose: The combination of a platinum and taxane are standard of care for many cancers, but the utility is often limited due to debilitating neurotoxicity. We examined whether single-nucleotide polymorphisms (SNP) from annotated candidate genes will identify genetic risk for chemotherapyinduced neurotoxicity. Patients and Methods: A candidate–gene association study was conducted to validate th...

Bortezomib-induced peripheral neurotoxicity: still far from a painless gain.